Fatal dapsone agranulocytosis in a Melanesian

Dapsone agranulocytosis in a leprosy patient.

Dapsone-induced agranulocytosis is a rare adverse effect. There are various reports of agranulocytosis in patients treated with dapsone for malaria prophylaxis and other dermatological diseases. However, this adverse reaction in leprosy is not often encountered. We describe agranulocytosis in a young patient who was taking dapsone (100 mg) for borderline-tuberculoid leprosy in a rural environment.

Report on a Fatal Case of Agranulocytosis

Dapsone-induced agranulocytosis in patients with Hansen's disease*

How to cite this article: Contin LA, Rocha VB. Pseudo “fringe sign” in frontal fibrosing alopecia. An Bras Dermatol. 2017;92(6): 892-4. Dear Editor, Agranulocytosis induced by sulphonamide or dapsone (44-diaminodiphenylsulphone – DDS) is characterized by a low concentration or absence of granulocytes due to sulfone cytotoxicity effects on bone marrow and mononuclear cells.1 DDS is a structural ...

Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).

A case of agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone) is described. At the recommended dose of one tablet weekly this is apparently a rare occurrence but highlights one of the hazards in a changing climate of malarial prophylaxis in which the use of Maloprim is increasing.

Fatal agranulocytosis due to phenylindanedione: report of a case.

PHENYLINDANEDIONE is one of several oral anticoagulants in wide use at the present time. It is generally considered to be non-toxic, but adverse reactions to the drug have been reported. We have been able to find six instances of agranulocytosis, two of jaundice,' and six of rash without fever 13 in the world literature. One of the instances of agranulocytosis was fatal. The purpose of this com...